Search by TCR name or by T Cell receptor alpha/beta variable genes (TRAV/TRBV)
Name: A6
Search by MHC allele or view all entries for an MHC class
Allele: HLA-A*02:01
Search for entries with experimental binding energies below input ΔG in kcal mol-1
ΔG (kcal mol-1) < -6.00
Search for entries containing a peptide with input amino acid sequence. Sub-sequences are allowed. Case-insensitive.
Peptide sequence: LFGYPVY
Each ATLAS entry (row) of the search results corresponds to a unique TCR-pMHC complex with an experimentally determined binding affinity and a 3D structure or similar structure which can be used as a template for design.
The PDB column refers to the Protein Data Bank (PDB) ID for a structure matching the TCR-pMHC complex with the reported experimental binding affinity, ΔG (kcal mol-1).
The Template PDB column refers to the PDB ID for a template structure such that a TCR-pMHC complex matching the reported binding affinity may be generated from this structure by modeling the mutations described in the TCR mutation, MHC mutation, and Peptide mutation columns. The TCR mutation chain and MHC mutation chain refer to the protein chain (A for alpha and B for beta) carrying the TCR and MHC mutations, respectively.
Selecting the Template PDB for the D26W TCR mutant in the results example brings you to the PV-JavaScript Protein Viewer allowing you to view the selected structure and the Rosetta designed mutations. The individual template structures and Rosetta designed structures are available for download. For uniformity all structures carry the following adjustments: renaming of chains, truncation of chains to binding interface, and removal of water moleculues.