What is ATLAS?
The ATLAS (Altered TCR Ligand Affinities and Structures) database is a manually curated repository containing the binding affinities for wild-type and mutant T cell receptors (TCRs) and their antigens, peptides presented by the major histocompatibility complex (MHC). The database links experimentally measured binding affinities with the corresponding three dimensional structures for TCR-pMHC complexes.
The user can browse and search ↗ affinities, structures, and experimental details for TCRs, peptides, and MHCs of interest. We aim to facilitate the development of next-generation protein design algorithms targeting the TCR-pMHC interface. With this in mind, ATLAS is designed to be easily parsed using modeling software that builds protein structures for training and testing. All collections of structures, affinities, and statistics in ATLAS are available for download ↗.
Last Update: 08.15.2023
Total entries
1174
Human
1066
Mouse
108
Class I MHC
849
Class II MHC
325
PDB structures
803
Statistics:
Total entries: 1174
Human: 1066
Mouse: 108
Class I MHC: 849
Class II MHC: 325
PDB structures: 803
